{"id":526,"date":"2022-09-28T23:49:51","date_gmt":"2022-09-28T15:49:51","guid":{"rendered":"https:\/\/damakey.com\/?p=526"},"modified":"2023-05-24T15:53:46","modified_gmt":"2023-05-24T07:53:46","slug":"%e4%b9%b3%e9%85%b8%e6%98%af%e9%81%8b%e5%8b%95%e7%9a%84%e5%a5%bd%e6%9c%8b%e5%8f%8b","status":"publish","type":"post","link":"https:\/\/damakey.com\/?p=526","title":{"rendered":"\u4e73\u9178\u662f\u904b\u52d5\u7684\u597d\u670b\u53cb"},"content":{"rendered":"

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\u559c\u6b61\u904b\u52d5\u7684\u670b\u53cb\u8981\u4e86\u89e3\uff0c\u904b\u52d5\u904e\u7a0b\u4e2d\u7522\u751f\u7684\u4e73\u9178<\/span>(<\/span>\u4e73\u9178\u9e7d<\/span>)<\/span>\u4e0d\u4f46\u4e0d\u6703\u4fc3\u9032\u75b2\u52de\uff0c\u53cd\u800c\u5728\u8eab\u9ad4\u63a5\u7e8c\u4ee3\u8b1d\u5b83\u6642\uff0c\u5c07\u5b83\u8b8a\u6210\u80fd\u91cf\u7684\u4f86\u6e90\u4e4b\u4e00\uff0c\u4e73\u9178\u5176\u5be6\u662f\u904b\u52d5\u7684\u597d\u670b\u53cb\u3002\u6211\u5011\u6703\u611f\u5230\u75b2\u52de\uff0c\u662f\u904b\u52d5\u904e\u7a0b\u4e2d\u5176\u4ed6\u4ee3\u8b1d\u7269\u5806\u7a4d\u6240\u81f4\u3002<\/span><\/p>\n

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\u5148\u4e86\u89e3\u4e00\u4e0b\u904b\u52d5\u6240\u9700\u7684\u80fd\u91cf\uff0c\u90a3\u662f\u900f\u904e\u4e00\u500b\u300c\u7cd6\u89e3\u300d\u7684\u904e\u7a0b\uff0c\u7531\u8461\u8404\u7cd6\u7522\u751f\u4e19\u916e\u9178\uff0c\u7136\u5f8c\u8f49\u63db\u6210\u4e73\u9178\u6216\u80fd\u91cf\u7684\u3002<\/span><\/p>\n

<\/span><\/p>\n

\u300e<\/span>……<\/span>\u6bcf\u4e00\u689d\u808c\u7e96\u7dad\u7684\u4e73\u9178\u90fd\u662f\u900f\u904e\u7cd6\u89e3\u4f5c\u7528\u7522\u751f\uff0c\u5728\u6700\u5f8c\u968e\u6bb5\uff0c\u6703\u5f62\u6210\u4e19\u916e\u9178\uff0c\u4e4b\u5f8c\u6709\u5169\u689d\u8def\u53ef\u9078\uff1a\u53ef\u4ee5\u900f\u904e\u4e73\u9178\u812b\u6c2b\u9176<\/span>(Lactate Dehydrogenize, LDH)<\/span>\u8f49\u5316\u6210\u4e73\u9178\uff0c\u6216\u900f\u904e<\/span>PDH<\/span>\u8f49\u5316\u6210\u4e59\u91af\u8f14\u9176<\/span>A<\/span>\uff0c\u9032\u5165\u7c92\u817a\u9ad4\u4f9b\u514b\u6c0f\u5faa\u74b0\u4f7f\u7528\uff0c\u4e26\u4ee5\u6709\u6c27\u7684\u65b9\u5f0f\u7522\u751f\u80fd\u91cf\u3002\u4e19\u916e\u9178\u8f49\u5316\u6210\u8f49\u5316\u6210\u4e59\u91af\u8f14\u9176<\/span>A<\/span>\u4e26\u9032\u5165\u7c92\u817a\u9ad4\uff0c\u6216\u8f49\u5316\u6210\u4e73\u9178\uff0c\u53d6\u6c7a\u65bc\u8a31\u591a\u56e0\u7d20\uff0c\u5305\u62ec<\/span>LDH<\/span>\u548c<\/span>PDH<\/span>\u9175\u7d20\u6fc3\u5ea6\u53ca\u6d3b\u6027<\/span>……<\/span>\u8207\u666e\u904d\u8a8d\u77e5\u76f8\u53cd\uff0c\u5c31\u7b97\u6c92\u6709\u5145\u8db3\u7684\u6c27\u6c23\u4e5f\u6703\u767c\u751f\u4e73\u9178\u8f49\u5316\u3002\u300f<\/span>*<\/span><\/p>\n

<\/span><\/p>\n

PDH<\/span>\u662f\u4e19\u916e\u9178\u53bb\u6c2b\u9176<\/span>(Pyruvate dehydrogenase, PDH)<\/span>\u3002<\/span><\/p>\n

<\/span><\/p>\n

\u4e73\u9178\u7522\u751f\u4e4b\u5f8c\uff0c\u8eab\u9ad4\u5728\u6e05\u9664\u4e73\u9178\u7684\u904e\u7a0b\uff0c\u4e5f\u6703\u5229\u7528\u4e73\u9178\u7522\u751f\u80fd\u91cf\u3002<\/span><\/p>\n

<\/span><\/p>\n

\u300e<\/span>……<\/span>\u808c\u8089\u7d30\u80de\u53ef\u900f\u904e\u7c92\u817a\u9ad4\u4f7f\u7528\u548c\u6c27\u5316\u7d30\u80de\u5167\u7684\u4e73\u9178\uff0c\u76f4\u63a5\u5c07\u4e4b\u4f5c\u70ba\u80fd\u91cf\u4f86\u6e90\uff1b\u56e0\u6b64\u4e73\u9178\u53ef\u4f9b\u808c\u7e96\u7dad\u4f7f\u7528\uff0c\u6216\u9001\u81f3\u9130\u8fd1\u808c\u7e96\u7dad\u4f9b\u5176\u5229\u7528\uff1b\u6b64\u5916\uff0c\u5b83\u9084\u80fd\u88ab\u9001\u81f3\u9593\u8cea\u8154<\/span>(<\/span>\u808c\u8089\u7d30\u80de\u5468\u570d<\/span>\/<\/span>\u4e4b\u9593\u7684\u7a7a\u8154<\/span>)<\/span>\u4f7f\u7528\u3002<\/span>……<\/span>\u9032\u5165\u8840\u6d41\u4e2d\u7684\u4e73\u9178\u53ef\u900f\u904e\u591a\u7a2e\u65b9\u5f0f\u6e05\u9664\u3002\u808c\u7e96\u7dad\u5149\u8b5c\u504f\u5411\u6162\u7e2e\u808c\u7aef\u7684\u808c\u7e96\u7dad\u6703\u53d6\u7528\u8840\u4e2d\u7684\u4e73\u9178\uff0c\u4f5c\u70ba\u80fd\u91cf\u4f86\u6e90\u3002\u672a\u6d88\u8017\u592a\u591a\u7684\u808c\u7e96\u7dad\u4e5f\u6703\u4f7f\u7528\u8840\u4e2d\u7684\u4e73\u9178\uff1b\u9664\u6b64\u4e4b\u5916\uff0c\u5fc3\u81df\u3001\u5927\u8166\u548c\u809d\u81df\u5c0d\u65bc\u6e05\u9664\u4e73\u9178\u90fd\u5f88\u91cd\u8981\u3002\u5fc3\u81df\u548c\u5927\u8166\u6703\u7528\u4e73\u9178\u4f5c\u70ba\u80fd\u91cf\u4f86\u6e90\uff0c\u800c\u809d\u81df\u5247\u900f\u904e\u67ef\u6c0f\u5faa\u74b0\uff0c\u5c07\u4e73\u9178\u8f49\u5316\u70ba\u4e19\u916e\u9178\uff0c\u6700\u5f8c\u4f5c\u70ba\u80fd\u91cf\u4f86\u6e90\u8461\u8404\u7cd6\u3002\u6b64\u904e\u7a0b\u7a31\u70ba\u4e73\u9178\u7a7f\u68ad<\/span>(Lactate shuttle)<\/span>\uff0c\u4e5f\u5c31\u662f\u4e73\u9178\u5728\u808c\u8089\u4e2d\u751f\u6210\uff0c\u7136\u5f8c\u7d93\u8840\u6d41\u9001\u81f3\u4f7f\u7528\u90e8\u4f4d\uff0c\u4f5c\u70ba\u808c\u7e96\u7dad\u6216\u5176\u4ed6\u7d44\u7e54\u6216\u5668\u5b98\u7684\u80fd\u91cf\u4f86\u6e90\u3002\u64da\u63a8\u6e2c\u6b64\u70ba\u8eab\u9ad4\u5c07\u5132\u5099\u80fd\u91cf\u9001\u81f3\u4e0d\u540c\u808c\u8089\u7684\u4e00\u7a2e\u65b9\u5f0f\uff0c\u56e0\u70ba\u5132\u5099\u5f62\u5f0f\u7684\u809d\u91a3\u7121\u6cd5\u904b\u9001\u3002\u300f<\/span>*<\/span><\/p>\n

<\/span><\/p>\n

\u548c\u4e00\u822c\u4eba\u7684\u60f3\u6cd5\u4e0d\u540c\uff0c\u4e73\u9178\u4f5c\u70ba\u80fd\u91cf\u4f86\u6e90\u4e4b\u4e00\uff0c\u4e0d\u6b62\u4e0d\u662f\u75b2\u52de\u7684\u539f\u56e0\uff0c\u9084\u53ef\u4ee5\u5ef6\u7de9\u75b2\u52de\u7684\u7522\u751f\u5462\uff01<\/span><\/p>\n

<\/span><\/p>\n

\u904b\u52d5\u7684\u75b2\u52de\u611f\uff0c\u662f\u8eab\u9ad4\u5728\u544a\u8a34\u5927\u8166\u5b83\u5df2\u7d93\u6162\u6162\u8d85\u51fa\u8ca0\u8377\uff0c\u6240\u4ee5\u5927\u8166\u5c31\u6703\u5354\u8abf\u8eab\u9ad4\u800c\u5c07\u904b\u52d5\u7684\u901f\u5ea6\u6162\u4e0b\u4f86\uff0c\u662f\u4e00\u500b\u4fdd\u8b77\u6a5f\u5236\u3002\u6240\u4ee5\uff0c\u5982\u679c\u80fd\u5920\u5ef6\u7de9\u75b2\u52de\u611f\u7684\u7522\u751f\uff0c\u5c31\u53ef\u4ee5\u589e\u52a0\u5728\u904b\u52d5\u8868\u73fe\u4e0a\u7684\u8010\u529b\u4e86\u3002<\/span><\/p>\n

<\/span><\/p>\n

\u6709\u4e09\u7a2e\u75b2\u52de\u7684\u7406\u8ad6\uff0c\u53ef\u5206\u5225\u63d0\u4f9b\u6211\u5011\u601d\u8003\u589e\u52a0\u8010\u529b\u7684\u8a13\u7df4\u7b56\u7565\u3002<\/span><\/p>\n

<\/span><\/p>\n

\u7b2c\u4e00\u7a2e\u75b2\u52de\u7406\u8ad6\uff1a\u4e73\u9178<\/span>\/<\/span>\u526f\u7522\u7269\u7406\u8ad6<\/span><\/p>\n

<\/span><\/p>\n

\u6211\u5011\u5df2\u7d93\u4e86\u89e3\uff0c\u4e73\u9178\u4e26\u4e0d\u662f\u75b2\u52de\u7684\u539f\u56e0\uff0c\u75b2\u52de\u4e3b\u8981\u662f\u5176\u4ed6\u4ee3\u8b1d\u526f\u7522\u7269\u5806\u7a4d\u6240\u81f4\uff0c\u4f46\u662f\u56e0\u70ba\u526f\u7522\u7269\u548c\u4e73\u9178\u91cf\u9ad8\u5ea6\u76f8\u95dc\uff0c\u6240\u4ee5\u6211\u5011\u5c31\u5c07\u4e4b\u7a31\u70ba\u300c\u4e73\u9178<\/span>\/<\/span>\u526f\u7522\u7269\u7406\u8ad6\u300d\u3002<\/span><\/p>\n

<\/span><\/p>\n

\u4e73\u9178<\/span>\/<\/span>\u526f\u7522\u7269\u7406\u8ad6\u7684\u904b\u52d5\u7b56\u7565\u5c31\u662f\uff0c\u300e<\/span>……<\/span>\u6211\u5011\u53ef\u4ee5\u6e1b\u6162\u5806\u7a4d\u7684\u901f\u5ea6\u6216\u63d0\u5347\u53ef\u5806\u7a4d\u7684\u6700\u5927\u5bb9\u91cf\uff0c\u5c31\u80fd\u5ef6\u5f8c\u75b2\u52de\uff0c\u904b\u52d5\u8868\u73fe\u4e5f\u6703\u6709\u6240\u9032\u6b65\u3002\u300f<\/span>*<\/span><\/p>\n

<\/span><\/p>\n

\u7b2c\u4e8c\u7a2e\u75b2\u52de\u7406\u8ad6\uff1a\u808c\u7e96\u7dad\u7406\u8ad6<\/span><\/p>\n

<\/span><\/p>\n

\u300e\u5728\u6b64\u6a21\u578b\u4e2d\uff0c\u8a8d\u70ba\u75b2\u52de\u662f\u808c\u7e96\u7dad\u7684\u795e\u7d93\u5fb5\u53ec\u548c\u7e96\u7dad\u672c\u8eab\u7684\u8010\u529b<\/span>(<\/span>\u6216\u4e00\u689d\u808c\u7e96\u7dad\u53ef\u4ee5\u4fdd\u6301\u53d7\u5230\u5fb5\u53ec\u800c\u4e0d\u6703\u611f\u5230\u75b2\u52de\u7684\u6642\u9593<\/span>)<\/span>\u4e00\u8d77\u9020\u6210\u3002\u7576\u8eab\u9ad4\u611f\u5230\u75b2\u52de\uff0c\u808c\u7e96\u7dad\u5c31\u6703\u958b\u59cb\u300c\u7121\u529b\u300d\uff0c\u4e26\u5fb5\u53ec\u5176\u4ed6\u7684\u808c\u7e96\u7dad\u4f86\u586b\u88dc\u5176\u7a7a\u7f3a\u3002\u5230\u4e86\u6700\u5f8c\uff0c\u5927\u90e8\u5206\u808c\u7e96\u7dad\u90fd\u75b2\u4e4f\u4e86\uff0c\u7121\u6cd5\u7dad\u6301\u5fc5\u8981\u7684\u529b\u91cf\u751f\u6210\uff0c\u9019\u6642\u5019\u8eab\u9ad4\u5c31\u6703\u75b2\u52de\uff0c<\/span>……<\/span>\u300f<\/span>*<\/span><\/p>\n

<\/span><\/p>\n

\u7531\u808c\u7e96\u7dad\u7406\u8ad6\uff0c\u5982\u679c\u8981\u589e\u52a0\u6574\u9ad4\u8010\u529b\uff0c\u5c31\u8981\u589e\u52a0\u808c\u7e96\u7dad\u5132\u5b58\u91cf\u4e26\u52a0\u5f37\u808c\u7e96\u7dad\u7684\u8010\u529b\u3002\u53ef\u4ee5\u591a\u505a\u77ed\u8dd1\u3001\u5761\u5730\u77ed\u8dd1<\/span>\/<\/span>\u767b\u9ad8\u722c\u5761\uff0c\u6216\u8209\u91cd\u7b49\u904b\u52d5\u3002<\/span><\/p>\n

<\/span><\/p>\n

\u7b2c\u4e09\u7a2e\u75b2\u52de\u7406\u8ad6\uff1a\u7c21\u55ae\u75b2\u52de\u6574\u9ad4\u6a21\u578b<\/span><\/p>\n

<\/span><\/p>\n

\u7c21\u55ae\u75b2\u52de\u6574\u9ad4\u6a21\u578b\u57fa\u672c\u4e0a\u662f\u7d50\u5408\u300c\u4e73\u9178<\/span>\/<\/span>\u526f\u7522\u7269\u7406\u8ad6\u300d\u548c\u300c\u808c\u7e96\u7dad\u7406\u8ad6\u300d\u3002\u9664\u524d\u9762\u5169\u500b\u7406\u8ad6\u7684\u7b56\u7565\u4e4b\u5916\uff0c\u300c\u7c21\u55ae\u75b2\u52de\u6574\u9ad4\u6a21\u578b\u300d\u5efa\u8b70\u53ef\u4ee5\u900f\u904e\u8a13\u7df4\uff0c\u8b93\u81ea\u5df1\u6709\u4fe1\u5fc3\u8010\u53d7\u66f4\u591a\u904b\u52d5\u904e\u7a0b\u7684\u526f\u7522\u7269\uff0c\u5ef6\u7de9\u5927\u8166\u767c\u51fa\u505c\u6b62\u52d5\u4f5c\u7684\u6642\u9593\u3002\u5728\u505a\u904b\u52d5\u8a13\u7df4\u6642\uff0c\u9010\u6f38\u589e\u52a0\u9577\u5ea6\u8207\u5f37\u5ea6\uff0c\u6311\u6230\u81ea\u5df1\u7684\u5fcd\u53d7\u5ea6\uff0c\u662f\u9019\u500b\u7b56\u7565\u7684\u5171\u540c\u7279\u5fb5\u3002<\/span><\/p>\n

<\/span><\/p>\n

\u4e0d\u7ba1\u662f\u54ea\u4e00\u7a2e\u7406\u8ad6\uff0c\u7528\u9032\u9000\u5ee2\u6c38\u9060\u662f\u771f\u7406\uff0c\u904b\u52d5\u8981\u6301\u4e4b\u4ee5\u6046\u3002\u808c\u8089\u7684\u7e96\u7dad\u3001\u5fc3\u80ba\u7684\u529f\u80fd\u3001\u8eab\u9ad4\u548c\u5927\u8166\u7684\u5354\u8abf\uff0c\u90fd\u6703\u56e0\u70ba\u4e2d\u65b7\u904b\u52d5\u800c\u53d7\u5230\u5f71\u97ff\u3002\u4ee5\u767b\u5c71\u70ba\u4f8b\uff0c\u300c\u4e00\u500b\u6708\u4e0d\u722c\u5c71\uff0c\u81ea\u5df1\u6703\u767c\u73fe\uff1b\u4e8c\u500b\u6708\u4e0d\u722c\u5c71\uff0c\u6709\u4e9b\u968a\u53cb\u6703\u767c\u73fe\uff1b\u4e09\u6708\u6708\u4e0d\u722c\u5c71\uff0c\u5168\u968a\u7684\u968a\u53cb\u90fd\u6703\u767c\u73fe\u300d\uff0c\u6703\u767c\u73fe\u4e0d\u722c\u5c71\u7684\u4eba\u9ad4\u529b\u660e\u986f\u7684\u8870\u9000\u3002<\/span><\/p>\n

<\/span><\/p>\n

\u6211\u66fe\u76ee\u7779\u5df2\u7d93\u722c\u5b8c\u767e\u5cb3<\/span>(<\/span>\u5b8c\u767e<\/span>)<\/span>\u800c\u4e14\u64d4\u4efb\u904e\u56ae\u5c0e\u7684\u8cc7\u6df1\u9ad8\u624b\u4e2d\u7684\u9ad8\u624b\uff0c\u56e0\u70ba\u5c07\u8fd1\u4e00\u5e74\u6c92\u722c\u767e\u5cb3\uff0c\u4e00\u500b\u5c0f\u5c0f\u7684\u4e0a\u5761\uff0c\u7576\u6642\u9023\u6211\u9019\u500b\u83dc\u9ce5\u4ed6\u90fd\u8ddf\u4e0d\u4e0a\u4e86\u5462\uff01\u771f\u662f\u60c5\u4f55\u4ee5\u582a\u3002<\/span><\/p>\n

<\/span><\/p>\n

\u4e73\u9178\u662f\u904b\u52d5\u7684\u597d\u670b\u53cb\uff0c\u4e0b\u6b21\u904b\u52d5\u611f\u5230\u75b2\u5026\u4e0d\u8981\u518d\u602a\u5b83\u4e86\u3002\u591a\u904b\u52d5\uff0c\u589e\u5f37\u808c\u7e96\u7dad\u7684\u5132\u5b58\u91cf\u548c\u8010\u53d7\u5ea6\uff0c\u5c31\u53ef\u4ee5\u589e\u5f37\u904b\u52d5\u8868\u73fe\u7684\u8010\u529b\u4e86\u3002\u9053\u7406\u5f88\u7c21\u55ae\uff0c\u505a\u8d77\u4f86\u4e5f\u4e0d\u96e3\uff0c\u53ea\u8981\u52d5\u8d77\u4f86\u3002<\/span><\/p>\n

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*<\/span>\uff1a\u300a\u8dd1\u6b65\u7684\u79d1\u5b78\u8207\u5be6\u52d9\u300b\uff0c\u53f2\u8482\u82ac·\u9ea5\u683c\u5c3c\u65af<\/span> <\/span>\u8457\uff0c\u7530\u6615\u65fb<\/span> <\/span>\u8b6f<\/span><\/p>\n

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2022\/9\/19 <\/span>\u4e73\u9178\u662f\u904b\u52d5\u7684\u597d\u670b\u53cb<\/span> Damakey<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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